Spironolactone Tablets for Hypertension as an Adjunctive Drug in The Treatment of Hypertension

• Transport Package: Box
• Specification: 20mg*100tab/box
• Trademark: FUL
• Origin: China
• Model NO.: FC28-1
• Production Capacity: 10000PCS/

Product Description

Item Name:spironolactone tablets
Molecular formula:C₂₄H₃₂O₄S

Item Description

Item nanme:spironolactone tablets
Item character:This product is white

Indication:
1. Edema diseases combined with other diuretics in the treatment of edema diseases such as congestive edema, ascites due to liver cirrhosis and renal edema. The purpose is to correct the secondary increase of aldosterone secretion associated with the above diseases and to counteract the potassium excretion effect of other diuretics. It is also used in the treatment of idiopathic edema.
2. Hypertension as an adjunctive drug in the treatment of hypertension.
3. Spironolactone can be used in the diagnosis and treatment of primary aldosteronism.
4. The prevention of hypokalemia is combined with thiazide diuretics to enhance diuretic effect and prevent hypokalemia.

Item specifications:20mg*100tab/box

Usage and dosage:1 adult [1]
In the treatment of edematous diseases, 40-120mg (2-6 tablets) per day was taken 2-4 times for at least 5 days. The dosage should be adjusted in the future.
In the treatment of hypertension, 40-80mg (2-4 tablets) should be taken daily for at least 2 weeks. After that, the dosage should be adjusted as appropriate. It is not suitable to be combined with angiotensin converting enzyme inhibitor to avoid increasing the chance of hyperkalemia.
In the treatment of primary aldosteronism, patients were given 100-400mg (5-20 tablets) daily before operation, 2-4 times. For patients who are not suitable for operation, a smaller dose is used.
Diagnosis of primary aldosteronism. Long term trial, 400mg (20 tablets) daily, 2-4 times for 3-4 weeks. In the short-term trial, 400mg (20 tablets) was taken 2-4 times a day for 4 consecutive days. The elderly are more sensitive to this drug, and the initial dosage should be smaller.
2 children
In the treatment of edematous diseases, the dosage was adjusted according to the weight of 1-3mg / kg or body surface area of 30-90mg / m2, once or in two to four times daily for 5 days. The maximum dose was 3-9mg / kg or 90-270mg / m2 per day

Adverse reactions
1. Common problems are as follows:
(1) Hyperkalemia is the most common, especially when taking medicine alone, eating high potassium diet, taking potassium or potassium containing drugs such as penicillin potassium, and there are renal function damage, oliguria, anuria; even if combined with thiazide diuretics, the incidence of hyperkalemia can still reach 8.6% - 26%, and arrhythmia is the first manifestation, so it is necessary to closely follow up the blood potassium and ECG during medication;
(2) Gastrointestinal reactions, such as nausea, vomiting, gastrospasm and diarrhea, have been reported to cause peptic ulcer.
2
(1) Hyponatremia is rare when used alone, and the incidence of hyponatremia increases when combined with other diuretics;
(2) Long term use of this drug can cause breast development, impotence and low sexual function in men, and can cause breast swelling and pain, voice coarsening, increased hair, menstrual disorders and decreased sexual function in women;
(3) Central nervous system manifestations, long-term or large dose of this drug can occur walking uncoordinated, headache and so on.
3
(1) Allergic reaction, rash and even dyspnea;
(2) The temporary increase of plasma creatinine and urea nitrogen is mainly related to excessive diuresis, insufficient effective blood volume and decrease of glomerular filtration rate;
(3) Mild perchloric acidosis;
(4) 5 cases of breast cancer were reported after long-term use of this drug and hydrochlorothiazide.

Taboo:
Hyperkalemia is forbidden

Matters needing attention:
1. Use with caution in the following situations:
(1) No urine.
(2) Renal insufficiency.
(3) Liver function is not complete, because this medicine causes electrolyte disorder, can induce liver coma.
(4) Hyponatremia.
(5) On the other hand, it can aggravate the hyperacidosis.
(6) Breast enlargement or menstrual disorder.
2. The administration should be individualized, starting from the minimum effective dose, so as to reduce the occurrence of side effects such as electrolyte disturbance. If you take medicine once a day, you should take medicine in the morning to avoid the increase of urination at night.
3. The blood potassium concentration of patients should be known before medication, but in some cases, the blood potassium concentration does not represent the total amount of potassium in the body. For example, when acidosis occurs, potassium is transferred from intracellular to extracellular and hyperkalemia is easy to occur. After acidosis is corrected, the blood potassium can be decreased.
4. The action of this drug is slow and the maintenance time is long, so the first day dose can be increased to 2-3 times of the conventional dose, and the dose can be adjusted as appropriate later. When combined with other diuretics, it can be taken 2-3 days before other diuretics. The dosage of other diuretics can be reduced by 50% in the first 2-3 days, and the dosage can be adjusted accordingly. At the time of withdrawal, the drug should be stopped 2-3 days before other diuretics.
5. In case of hyperkalemia, the drug should be stopped immediately.
6. The drug should be taken at the time of eating or after meals to reduce gastrointestinal reactions and possibly improve the bioavailability of the drug.
7. Interference to diagnosis
(1) The concentration of plasma cortisol measured by fluorescence method is increased, so the drug should be stopped or other methods should be used 4-7 days before blood collection.
(2) When the following measured values are increased, plasma creatinine and urea nitrogen (especially when the original renal function is damaged), plasma renin, serum magnesium and potassium, urinary calcium excretion may be increased, while urinary sodium excretion may be decreased.
8. Athletes should use it carefully.

Medication for pregnant and lactating women:
The drug can pass through the placenta, but its effect on the fetus is unclear. Pregnant women should use drugs under the guidance of doctors, and the medication time should be as short as possible

Company Profile

 

FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese

Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages

Our Service
a)  Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.

Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises  CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.




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