The main component of this product is penicillin sodium.
Chemical name: (2S, 5R, 6R) - 3,3-dimethyl-6 - (2-phenylacetylamino) - 7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid sodium salt.
Chemical structural formula:
Molecular formula: c16h17n2nao4s
Molecular weight: 356.38
Product Description
Item Name: BSI-001
Character broadcast
This product is white crystalline powder.
Indication
Penicillin is suitable for various infections caused by sensitive bacteria, such as abscess, bacteremia, pneumonia and endocarditis.
Penicillin is the drug of choice for the following infections:
1. Hemolytic streptococcal infection, such as pharyngitis, tonsillitis, scarlet fever, erysipelas, cellulitis and puerperal fever.
2. Streptococcus pneumoniae infection, such as pneumonia, otitis media, meningitis and bacteremia.
3. Penicillinase free Staphylococcus infection.
4. Anthrax.
5. Clostridium infection such as tetanus and gas gangrene.
6. Syphilis (including congenital syphilis).
7. Leptospirosis.
8. Return to fever.
9. Diphtheria.
10. Penicillin combined with aminoglycosides is used to treat Streptococcus viridis endocarditis.
Specifications
(1) 0.2miu (200000 units)
(2) 0.8miu (800000 units)
(3) 1.0miu (1 million units)
(4) 1.5miu (1.5 million units)
(5) 4.0miu (4 million units)
(3) 6.4miu (6.4 million units)
(4) 8.0miu (8 million units)
Usage and dosage
Penicillin was administered by intramuscular injection or intravenous drip.
1. Adults: intramuscular injection, 800000 ~ 2 million units a day, administered in 3 ~ 4 times; Intravenous drip: 2-20 million units a day, administered in 2-4 times.
2. Children: intramuscular injection, given once every 12 hours according to the weight of 25000 units / kg; Intravenous drip: the drug is administered 2-4 times a day according to the body weight of 50000-200000 units / kg.
3. Newborn (full-term): 50000 units / kg per time, intramuscular injection or intravenous drip; Once every 12 hours in the first week of life, once every 8 hours for those over a week, and once every 6 hours for severe infection.
4. Premature infants: each time according to the weight of 30000 units / kg, once every 12 hours in the first week of birth and once every 8 hours in the case of 2-4 weeks; Once every 6 hours.
5. Patients with renal dysfunction: Patients with mild or moderate renal impairment do not need to reduce the conventional dose. Patients with severe renal impairment should extend the dosing interval or adjust the dose. When the clearance rate of endogenous creatinine was 10 ~ 50ml / min, the administration interval was extended from 8 hours to 8 ~ 12 hours, or the administration interval remained unchanged and the dose was reduced by 25%; When the clearance rate of endogenous creatinine is less than 10ml / min, the administration interval is extended to 12 ~ 18 hours or each dose is reduced to 25% ~ 50% of the normal dose, but the administration interval remains unchanged.
6. During intramuscular injection, every 500000 units of penicillin potassium shall be dissolved in 1ml of sterilized water for injection, and more than 500000 units shall be added with 2ml of sterilized water for injection, and sodium chloride injection shall not be used as solvent; During intravenous drip, the administration speed shall not exceed 500000 units per minute to avoid central nervous system toxicity.
Adverse reaction
1. Allergic reaction: penicillin allergic reaction is common, including urticaria and other rashes, leucopenia, interstitial nephritis, asthma attack and serum disease type reaction; Anaphylactic shock is occasionally seen. Once it occurs, it must be rescued on site, and treatment measures such as keeping the airway unblocked, oxygen inhalation and the use of adrenaline and glucocorticoid must be taken.
2. Toxic reaction: rare, but when intravenous drip of large dose of this product or intrathecal administration, it can lead to convulsions, muscle clonus, coma and serious mental symptoms due to high concentration of cerebrospinal fluid (penicillin encephalopathy). This reaction is more common in infants, the elderly and patients with renal insufficiency.
3. Contradiction between hirschner's reaction and treatment: when penicillin is used to treat syphilis, leptospirosis and other diseases, the symptoms can be exacerbated due to the death of pathogens, which is called hirschner's reaction; Treatment contradiction is also seen in syphilis patients. It is caused by the rapid disappearance of syphilis lesions after treatment, the relatively slow tissue repair, or the contraction of fibrous tissue at the lesion, which hinders the function of organs.
4. Double infection: there may be double infection such as penicillin resistant Staphylococcus aureus, gram-negative bacilli or Candida.
5. The application of high-dose penicillin sodium can lead to heart failure due to the intake of a large amount of sodium salt.
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1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
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FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.
4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.
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Language Spoken:English,Chinese,Japanese
Company Profile
ITB Biopharm Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded ITB has been put into operation in many well-known pharmaceutical enterprises such as SIN OPHARM, NCPC&CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
ITB Biopharm Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present ITB Biopharm Co., Ltd has NCPC offical authorization to sell its Intermediates,APIs and Finished Prepartions which is produced by NCPC North Best and its own sister manufactures,then ITB Biopharm Co., Ltd is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
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