Chloramphenicol Injection for Typhoid and Other Salmonella Infections

• Name: Chloramphenicol Injection
• Sample: Free
• Transport Package: Box
• Specification: 2ml: 0.25g
• Trademark: FUL
• Origin: China
• Model NO.: YP102-1
• Production Capacity: 10000PCS/

Product Description

Item Name:chloramphenicol injection
Molecular formula:

Item Description

Item nanme: chloramphenicol injection
Item character: This product is colorless or light yellow clear liquid.

Indication:
1. Typhoid and other Salmonella infections: the drug is selected for typhoid and paratyphoid caused by sensitive strains. This product is generally not suitable for gastroenteritis infected by Salmonella. It can still be selected if the condition is serious and there is the possibility of sepsis.
2. Haemophilus influenzae type b meningitis resistant to ampicillin or Streptococcus pneumoniae, Neisseria meningitidis meningitis and sensitive gram-negative bacilli meningitis in patients allergic to penicillin. This product can be used as one of the selected drugs.
3. Brain abscess, especially otogenic, is often a mixed infection of aerobic and anaerobic bacteria.
4. Severe anaerobic infection, such as infection caused by Bacteroides fragilis, is especially suitable for those whose lesions involve the central nervous system. It can be combined with aminoglycoside antibiotics to treat abdominal infection and pelvic infection, so as to control the simultaneous aerobic and anaerobic infection.
5. When there are no other low toxicity antibiotics to replace, it is often combined with aminoglycosides to treat various serious infections caused by sensitive bacteria, such as sepsis and lung infection caused by Haemophilus influenzae, Salmonella and other gram-negative bacteria.
6. Rickettsia infection can be used for the treatment of Q fever, Rocky Mountain spotted fever, endemic typhoid fever, etc.

Item specifications: 2ml:0.25g

Usage and dosage:Intravenous drip after dilution. Adults 2 ~ 3G a day, given twice; Children were given 3 to 4 times according to their body weight of 25 ~ 50mg / kg a day; Newborns shall not exceed 25mg / kg a day and shall be given four times.

Adverse reactions
1. The toxic reaction to hematopoietic system is the most serious adverse reaction of chloramphenicol. There are two different forms( 1) Reversible bone marrow suppression related to dose is common in patients with blood drug concentration of more than 25mg / L. The clinical manifestation is anemia, accompanied by leucopenia and thrombocytopenia( 2) Bone marrow toxicity unrelated to dose is often manifested as severe and irreversible aplastic anemia. Patients with aplastic anemia can have an incubation period of several weeks to months, which is not easy to be found early. Its clinical manifestations include bleeding tendency caused by thrombocytopenia, such as ecchymosis, ecchymosis and epistaxis, as well as signs of infection caused by granulocytopenia, such as high fever, sore throat Gangrene, pallor, etc. Most aplastic anemia occurs after oral administration of chloramphenicol.
2. Hemolytic anemia can occur in some patients with congenital deficiency of glucose phosphate dehydrogenase.
3. Grey baby syndrome. The typical case occurs within 48 hours after birth. High dose chloramphenicol can be administered. Grey baby syndrome can occur after 3 ~ 4 days of treatment, and the blood drug concentration can be as high as 40 ~ 200mg / L. The clinical manifestations were abdominal distension, vomiting, progressive pallor, cyanosis, microcirculation disturbance, Non rising body temperature and irregular breathing. It often occurs when large doses of chloramphenicol are applied to preterm infants or newborns (more than 25mg / L per day according to body weight), and similar manifestations can also occur when adults or older children apply larger doses (about 100mg / L per day according to body weight). If the drug was stopped early, it could recover completely.
4. This product can induce bleeding tendency after long-term treatment, which may be related to bone marrow suppression, obstruction of vitamin K synthesis caused by reduction of intestinal flora, prolongation of prothrombin time, etc.
5. Peripheral neuritis and optic neuritis often occur during long-term treatment. Drug withdrawal as soon as possible is often reversible. There are also cases of optic nerve atrophy and blindness.
6. Allergic reactions are rare. It can cause various rashes, solar dermatitis and angioneuroedema. It is generally mild and can improve rapidly after stopping the drug.
7. Double infection can cause lung, gastrointestinal and urinary tract infections of Proteus, Pseudomonas aeruginosa, Staphylococcus aureus and fungi.
8. Gastrointestinal reactions, including diarrhea, nausea and vomiting.

Taboo:
It is forbidden for those who are allergic to this product.

Matters needing attention:
1. Since irreversible osteopenia may occur, this product should not be used in repeated courses.
2. Patients with liver and kidney function impairment should avoid using this product. If it must be used, reduce the application. If possible, monitor the blood drug concentration to make the peak concentration below 25mg / L and the valley concentration below 5mg / L. If the blood drug concentration exceeds this range, it can increase the risk of bone suppression.
3. The peripheral hemogram should be checked regularly during the treatment, and the reticulocyte count should be checked for long-term treatment, and the bone bond should be checked if necessary, so as to find the reversible bone suppression related to the dose in time, but the whole hemogram test can not predict the aplastic anemia that usually occurs after the completion of treatment.
4. Interference to diagnosis: when urine sugar is measured by copper sulfate method, patients with chloramphenicol can produce false positive reaction.
5. Dilute with 0.9% sodium chloride injection or 5% glucose injection. Before dilution, warm the solution first, then add it into the diluent, and shake it while diluting to avoid crystallization. Once crystallization or precipitation occurs, the liquid medicine can be heated in a hot water bath, shaken and placed for a while to dissolve the crystallization or precipitation. Strict inspection must be carried out after dilution. The solution shall be clear and can be used for injection if there are no insoluble particles or small crystals. Inject slowly.

Medication for pregnant and lactating women:
Because chloramphenicol can pass through the placental barrier, it may cause toxic reactions to preterm infants and full-term newborns, resulting in "grey infant syndrome". Therefore, it is not suitable to use this product during pregnancy, especially at the end of pregnancy or delivery. This product is secreted from milk and may cause adverse reactions to lactating infants, including serious bone marrow suppression. Therefore, this product is not suitable for lactating women. When it must be used, lactation should be suspended

FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese

Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages

Our Service
a)  Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.

Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the  authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.




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