Berberine Hydrochloride and Trimethoprim Capsules for Indication-Sensitive Bacteria Caused by Gastroenteritis

• Name: Trimethoprim Capsules
• Transport Package: Carton
• Specification: 20x15x15cm
• Trademark: FUL
• Origin: China
• Model NO.: CF067
• Production Capacity: 100000/Month

Product Description

Product name berberine trimethoprim capsule

Generic name berberine trimethoprim capsule

Main ingredients This product is compound preparation, its group is divided into: each capsule contains 100mg berberine hydrochloride, 50mg trimethoprim.

Indication-sensitive bacteria caused by gastroenteritis, bacterial dysentery and other intestinal infections.

Adverse reactions nausea, vomiting, drug rash, diarrhea, disappeared after drug withdrawal; Pruritus, rash, and occasionally severe exudative polymorphic erythema may occur; Occasionally can occur aseptic meningitis, headache, neck stiffness and other phenomena.

Contraindication 1 allergy to berberine hydrochloride, trimethoprim and sulfonamides is forbidden.

Glucose-6-phosphate dehydrogenase deficiency is contraindication in children.

Newborns and infants under 2 months old are prohibited.

Note 1 this product can cause hemolytic anemia, resulting in jaundice.

2 during the medication should pay attention to the blood examination, in a long course of treatment, taking a large dose, the elderly, malnutrition and taking antiepileptic drugs, prone to folic acid deficiency, such as peripheral blood leukocytes or platelets have been significantly reduced, should be stopped.

Pregnant women and lactating women. Because trimethoprim can pass through the placental barrier in fetal circulation and the blood concentration in amniotic fluid is close to the maternal blood concentration, the use of berberine and trimethoprim capsules during pregnancy must be decided after weighing the advantages and advantages. Because trimethoprim can be secreted into milk, its high blood concentration may interfere with the metabolism of folic acid in lactating infants. Although the problem has not been confirmed in humans, the application of berberine and trimethoprim capsules to lactating mothers must be decided after weighing the advantages and benefits

Children. Berberine hydrochloride can cause hemolytic anemia and jaundice, so glucose - phosphate dehydrogenase deficiency in children is contraindicated

Trimethoprim in Berberine Trimethoprim Capsules may interfere with folic acid metabolism in lactating infants Newborns and infants under months of age should not use this drug; Children are at random time, and the liver and kidney function is not perfect, and the dosage of drugs should be decreased at random

Elder medication Elder patients should pay attention to the blood examination when taking berberine trimethoprim capsule due to reduced resistance and weakened metabolic ability. If serious adverse reactions occur, the medication should be stopped immediately

1. The interaction between berberine hydrochloride and other drugs is not clear;

Trimethoprim; 2.

(1) Increased chances of leukopenia and thrombocytopenia when used together with bone marrow inhibitors;

(2) In combination with dapsone, the blood concentration of both increased, and the increase of dapsone blood concentration increased and aggravated the adverse reactions, especially the occurrence of n-methemoglobinemia;

(3) The combination of antitumor drugs and 2, 4-diaminopyrimidines should not be used in the interval of treatment with other folic acid antagonists because of the possibility of poor bone marrow regeneration or megaloblastic anemia;

(4) The combination of reserpine can increase the elimination of trimethoprim and shorten the plasma half-life;

(5) The combination of cyclosporine can increase renal toxicity;

(6) Disturb the metabolism of phenytoin in the liver, increase the half-life of phenytoin and reduce its clearance rate;

(7) Simultaneous use of procaine amine can reduce renal clearance and increase the plasma concentration of procaine amine metabolites.

No drug overdose

Drug toxicology Berberine hydrochloride and trimethoprim have synergistic antibacterial effect. Berberine hydrochloride has inhibitory effect on a variety of gram-positive and negative bacteria in vitro, among which it has strong inhibitory effect on hemolytic streptococcus, Staphylococcus aureus, Vibrio cholerae, Neisseria meningitidis, Shigella, Typhoid bacillus and diphtheria bacillus. It also has a certain inhibitory effect on amoeba. Trimethoprim mainly interferes with bacterial folate metabolism, selectively inhibits dihydrofolate reductase, and prevents nucleic acid synthesis. Therefore, the antibacterial effect of the combination of the two drugs was stronger than that of the single drug, and the drug-resistant strains were reduced.

Pharmacokinetics The oral absorption of berberine hydrochloride was poor, the oral absorption of trimethoprim was complete, and the peak concentration of the drug reached 2 hours after administration. After absorption, it is widely distributed to body fluids and tissues, and the concentrations in liver, kidney, spleen, muscle, bronchial secretions, saliva, vaginal secretions, prostate tissue and prostate fluid are all higher than those in blood. Trimethoprim can cross the blood-brain barrier, the placental barrier and is secreted into milk. Trimethoprim is mainly filtered through the glomeruli and excreted from the renal tubules, 50% to 60% in drug form and the remainder in the form of metabolites.

Storage Keep away from light and sealed.




FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese

Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages

Our Service
a)  Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.

Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.


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