Metformin Hydrochloride Tablets Used for Obese Type 2 Diabetes and Prevent Hypoglycemia

• Transport Package: Carton
• Specification: 20x15x15cm
• Trademark: FUL
• Origin: China
• Model NO.: CF017-1
• Production Capacity: 100000/Month

Product Description

[Drug name] General name: Metformin Hydrochloride Tablets

Commodity name: GV

English name: Metformin

Pinyin: Yansuan Erjiashuanggu Pian

Ingredients The main ingredients of this product are: metformin hydrochloride, and its chemical name is: 1, 1-dimethylformin hydrochloride.

[Properties] This product is a thin film garment piece, white or almost white after removing the coating.

1. This product is preferred to be used for type 2 diabetes, especially for obese type 2 diabetes, which fails to be treated by simple diet control and physical exercise. 2. For type 1 or type 2 diabetes mellitus, the combination of this product with insulin can increase the hypoglycemic effect of insulin, reduce the amount of insulin and prevent hypoglycemia. 3. This product can also be used in combination with sulfonylurea oral hypoglycemic agents to have a synergistic effect.

1. Take medicine according to the doctor's advice. This product should be used in small doses and gradually increased according to the patient's condition.

2. The usual starting dose of this product is 0.5g, twice a day; Or 0.85g once a day; Take it with a meal.

3. Add 0.5 g per week, or 0.85 g every 2 weeks, gradually increase to 2 g per day, divided into several doses.

4. The maximum recommended dose for adults is 2550 mg per day. For patients requiring further blood glucose control, the dose can be increased to 2550 mg/day (i.e., 0.85 g/session, three times a day).

5. For better tolerance, medication should be taken with three meals at a daily dose of more than 2 grams.

1. Common adverse reactions of this product include diarrhea, nausea, vomiting, stomach distension, fatigue, dyspepsia, abdominal discomfort and headache. 2. Other rare cases include abnormal stool, hypoglycemia, myalgia, dizziness, dizziness, abnormal fingernails, rash, increased sweating, abnormal taste, chest discomfort, chills, flu symptoms, hot flashes, palpitations, weight loss, etc. 3. Metformin reduces the absorption of vitamin B12, but rarely causes anemia. 4. Lactic acidosis caused by this product is rare in the therapeutic dose range.

1. Renal disease or renal dysfunction caused by heart failure (shock), acute myocardial infarction, and sepsis (serum creatinine level 1.5 mg/dl (male), ≥ 1.4 mg/dl (female) or abnormal creatinine clearance). 2. Congestive heart failure requiring medical treatment, and other serious heart and lung disorders. 3. Severe infection and trauma, major surgery, clinical hypotension and hypoxia, etc. 4. Known allergy to metformin hydrochloride. 5. Acute or chronic metabolic acidosis, including diabetic ketoacidosis with or without coma, and diabetic ketoacidosis requires insulin treatment. Alcoholics. 7. For those who receive intravascular injection of iodinated contrast agent, they may temporarily stop using this product. 8. Uncorrected deficiency of vitamin B12 and folic acid.

1. Regular examination of renal function during oral administration of this product can reduce the occurrence of lactic acid poisoning, especially for elderly patients, regular examination of renal function is recommended. Oral administration of this product was suspended pending surgery and X-ray examination with iodine. 2. Liver dysfunction: Some patients with lactic acidosis have liver dysfunction, so people with liver diseases should avoid using this product. 3. Stress state: During fever, infection and surgery, patients who take oral hypoglycemic drugs are prone to temporarily poor control of blood glucose. At this time, patients must temporarily stop using this product and switch to insulin. 4. For patients with type I diabetes, this product should not be used alone, but should be used together with insulin. 5. Hematological tests should be performed regularly. The treatment of megaloblastic anemia caused by this product is rare. If produce should be

[Special population medication] Children:

The maximum daily dose of this product for patients aged 10-16 years with type 2 diabetes is 2000 mg. It is not recommended for children under 10 years of age.



Precautions during pregnancy and lactation:

This product is not recommended for pregnant women. Lactating women should use this product with caution and should stop breastfeeding when it is necessary to use this product.



Precautions for the elderly:

Elderly patients over 65 years of age should use this product with caution and check renal function regularly. The maximum dose is usually not used. This product is not recommended in patients over 80 years of age unless the creatinine clearance test shows no decrease in renal function.

[Drug interactions] 1. No changes in pharmacokinetic parameters of metformin were observed in single dose combination of metformin and glibencaride. 2. When metformin is combined with furosemide (furosemide), AUC of metformin increases, but renal clearance does not change. At the same time, Cmax and AUC of furosemide were decreased, the final half-life was shortened, and renal clearance was not changed. 3. The renal tubules shedding cation drugs (such as ammonia chloride pyrazole microphones, digoxin, morphine, procainamide, quinidine, quinine, rennie for butyl, ammonia, benzene with organism, trimethoprim and vancomycin) theory may compete with metformin renal tubular transport system, interact, it is recommended that close monitoring, adjust the product and/or the dose of drug interaction. 4. When metformin was combined with cimetidine, the plasma and whole blood AUC of metformin increased. However, when the two drugs were combined with a single dose, no metformin clearance half-life was observed. The pharmacokinetics of cimetidine did not change. 5. Such as taking some drugs can cause elevated blood sugar at the same time, such as thiazide drugs or other, glucocorticoid, phenol thiazine diuretics, thyroid,, estrogen and oral contraceptives, phenytoin, nicotinic acid, quasi sympathetic nerve medicine, ion channel blockers and isoniazid to close monitoring of blood sugar, and, in these drug discontinuation should pay close attention to the occurrence of hypoglycemia. 6. Metformin does not bind to plasma proteins, so drugs that are highly protein-bound, such as salicylate, amphenylsulfamilamide, chloramphenicol, and prosulfonamide, are less likely to interact with each other than sulfonylureas, which mainly bind to serum proteins. 7. There is usually no transition period when patients switch from other oral hypoglycemic agents to this product for removal of sulfonylurea. Patients taking chloropropanube should pay close attention during the first 2 weeks of switching to this product, because chloropropanube has a longer retention in the body, which can easily lead to drug overdose and hypoglycemia. 8. Metformin has an anticoagulant tendency to increase warfarin. 9. Resin drugs can reduce absorption of metformin when taken together with this product.

[Pharmacological Effects] According to literature reports, this product is a hypoglycemic drug. This product can reduce the fasting and postprandial hyperglycemia of type diabetes patients, HBALC can decrease by 1% ~ 2%, the mechanism of this product may be: 1. Increased sensitivity of surrounding tissues to insulin and increased insulin - mediated glucose utilization. 2. Increase the use of glucose in non-insulin-dependent tissues, such as brain, blood cells, renal medulla, intestinal tract, skin, etc. 3. Inhibit liver gluconeogenesis and reduce glycogen output. 4. Inhibition of glucose uptake by intestinal wall cells. 5. Inhibit cholesterol biosynthesis and storage, and reduce blood triglyceride and total cholesterol levels. Different from the action of insulin, this product does not promote the synthesis of fat and has no obvious hypoglycemic effect on normal people. It generally does not cause hypoglycemia when applied alone to type diabetes mellitus.

To preserve in sealed condition.

[Specification] 0.85g

[Packaging Specification] Aluminum plastic packaging, 10 pieces per board, two plates per box.

[Validity] 24 months.

[Approval Number] National medicine approval H20023371


FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
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a)  Free amples can be provided.
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1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
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Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.


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