Ncpc Sterile API Procaine Benzylpenicillin or Penicillin G Procaine CAS 54-35-3

• Transport Package: 20bou/Drum
• Specification: 99%
• Trademark: NCPC
• Origin: China
• HS Code: 2941109900
• Production Capacity: 1billion/Year

Product Description

Product Name: Procaine Benzylpenicillin or Penicillin G Procaine
 

Synonyms: Procaine Benzylpenicillin, Penicillin G Procaine, Benzylpenicillin procaine, Procaine Penicillin G,  Novocaine Benzylpenicillin, Penicillin G Novocaine

CAS Number: 54-35-3

Characteristics: White or almost white crystalline powder

Assay:  96.0% ~ 102.0% Procaine Benzylpenicillin, Penicillin G Procaine

Formula:  C29H38N4O6S

Structure Formula: 

 

Package information: 20BOU/Drum
KEY Words: Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine, Penicillin G Novocaine API Raw Material Powder

Chemical Name: 2-diethylaminoethyl 4-aminobenzoate (6R)-(2-phenylacetamido) penicillinate monohydrate

Description:
Procaine Benzylpenicillin or Penicillin G Procainea combination of Penicillin G and Procaine.
Penicillin G is an antibiotic. That is why Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Some gram-negative organisms such as Neiserria gonorrhoeae and Neiserria meningitidis are also reported to be susceptible to penicillin G.
Penicillin G is also known as benzylpenicillin. Procaine is also known as Novacaine.
Benzylpenicillin contains a 6′ phenylacetyl side chain. In acid aqueous solutions, penicillin is reported to decompose into penillic acid and penilloic acid.
Procaine or Novocaine is a noted sodium channel blocker with a variety of inhibitory effects.
In skeletal muscle, procaine (Novocaine) has been reported to inhibit calcium-induced calcium release. Procaine is also noted to act as a DNA methylation inhibitor and it will cause demethylation and reactivation of methylation-silenced genes.
Procaine or novocaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound.
Procaine benzylpenicillin , also known as Procaine Penicillin G, is an antibiotic useful for the treatment of a number of bacterial infections. It is a form of penicillin which is a combination of benzylpenicillin and the local anaesthetic agent procaine. Following deep intramuscular injection, it is slowly absorbed into the circulation and hydrolysed to benzylpenicillin -- thus it is used where prolonged low concentrations of benzylpenicillin are required. This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings.

Usage:
Procaine Benzylpenicillin also know as Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine, Penicillin G Novocaine. It has both the function of Procaine and Penicillin. They work together.
Procaine Benzylpenicillin is a widely used substance in pharmaceutical area.

 

As a professional China Penicillin G Procaine, Procaine Penicillin G Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Procaine Benzylpenicillin, Benzylpenicillin Procaine, Penicillin G Novocaine API from China in China for almost 10 years.

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Procaine benzylpenicillin also known as penicillin G procaine, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine, Penicillin G Novocaine, is an antibiotic which will help the treatment of a lot of bacterial infections. Specifically, Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G API Raw Material Powder is widely indicated for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites. Benzylpenicillin Procaine, Penicillin G Novocaine is given by injection into a muscle.

 

However, there can be Side effects include pain at the site of injection, blood clotting problems, seizures, and allergic reactions including anaphylaxis, etc. Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G is also popularly utilized to treat syphilis. It is not recommended for the people who have a history of penicillin allergy or procaine allergy. Usage of Benzylpenicillin Procaine, Penicillin G Novocaine during pregnancy and breastfeeding is relatively safe. Procaine benzylpenicillin is in the penicillin and beta lactam family of medications. Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G acts via benzylpenicillin and will kill the bacterial. Procaine makes the combination long acting.[3]

In the year 1948,  Benzylpenicillin Procaine, Penicillin G Novocaine was firstly introduced for pharmaceutical use. It is the most effective and safe medicines needed in a health system.

 

Medical uses:

Specific indications for Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G are as following:

-Syphilis

In the United States, Bicillin C-R (a injectable suspension which 1.2 million units of benzathine penicillin and 1.2 million units of procaine penicillin per 4 ml) is not recommended for treating syphilis, because it contains only 50% the suggested dose of Benzylpenicillin Procaine, Penicillin G Novocaine. Medication errors have been made due to the confusion between Bicillin L-A & Bicillin C-R. As a result, changes in product packaging have been made; specifically, the statement "Not for the Treatment of Syphilis" has been added in red text to both the Bicillin CR and Billin CR 900/300 syringe labels.

-Together with Erythromycin, Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G is used to treat strep throat, given as one IM injection

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Benzylpenicillin Procaine, Penicillin G Novocaine is also used as an adjunct in the treatment of anthrax.

 

Adverse effects of Benzylpenicillin Procaine, Penicillin G Novocaine:

At high doses, procaine penicillin might cause seizures and CNS abnormalities due to the procaine present in it.

 

Mechanism of action of Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G:

This product is a form of penicillin which is a combination of benzylpenicillin and the local anaesthetic agent procaine. Following deep intramuscular injection, Benzylpenicillin Procaine, Penicillin G Novocaine will be absorbed into the circulation slowly and hydrolysed to benzylpenicillin. Therefore, Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G is used where prolonged low concentrations of benzylpenicillin are needed in the treatment.

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Main indexes of Penicillin G Novocaine (Penicillin G Procaine)

Testing Item	Standard	Result
Appearance Penicillin G Novocaine	White or almost white crystalline powder	Complies
Identification Penicillin G Procaine	IR spectrum complies with that of reference standard (IR)	Complies
pH (50mg/15ml H2O)	5.0 ~ 7.5	5.9
Specific Optical Rotation	+165°  ~ +180°	+172°
Moisture	2.8% ~ 4.2%	3.1%
Related Substances	Impurity A: Not more than the area of the corresponding peak in the chromatogram obtained with reference solution(c) ≤  0.024%	4-aminobenzoic acid:      0.003%
	Any other impurity (B, C, D, E): for each impurity not more than the area of the peak due to benzylpenicillin in the chromatogram obtained with the reference solution(c) ≤  1%	Not detected
Residual Solvents(GC)	n-Butanol ≤  5000ppm	89ppm
	Ethyl acetate ≤  5000ppm	8ppm
Bacterial Endotoxins	< 0.10IU/mg	< 0.10IU/mg
Procaine (HPLC)	39.0% ~ 42.0%	40.9%
Procaine Benzylpenicilln (Penicillin G Novocaine)	96.0% ~ 102.0%	99.4%
Sterility	Should comply	Complies

This product complies with both BP and EP standard.

Top Quality, China Pure Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine Powder/Substance factory in China; China Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine Raw Material Suppliers in China. China Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine API Manufacturers in China. 

 

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7. Our value information is "Quality is our culture"
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After Sales Service

a)  Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.
 

FAQ

1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese

Company Profile

 

ITB Biopharm Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded ITB has been put into operation in many well-known pharmaceutical enterprises such as NCPC&CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

ITB Biopharm Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present ITB Biopharm Co., Ltd has NCPC offical authorization to sell its Intermediates,APIs and Finished Prepartions which is produced by NCPC North Best and its own sister manufactures,then ITB Biopharm Co., Ltd is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
 

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