Sulfadiazine Tablets for Treatment and Prevention of Epidemic Cerebrospinal Meningitis Caused by Sensitive Meningococci

• Name: Prevention of Epidemic Cerebrospinal Meningitis
• Name1: Meningitis
• Name2: Sensitive Meningococci
• Name3: Cerebrospinal Meningitis
• Transport Package: Carton
• Specification: 20x15x15cm
• Model NO.: CF046-1
• Trademark: FUL
• Origin: China
• Production Capacity: 100000/Month

Product Description

[Drug name]



Common name: sulfadiazine tablets



Product Name: Sulfadiazine Tablets (Special 1)



Sulfadiazine Tablets



Pinyin full code: Huanganmidingpian



Main ingredients The main ingredients of this product are: sulfadiazine.
 

[Characteristics] This product is white or yellowish flakes; The color gradually darkens when it meets light.



Sulfonamides belong to broad-spectrum antimicrobial drugs, but due to the resistance of many common clinical pathogens to these drugs, they are only used for infections caused by sensitive bacteria and other sensitive pathogenic microorganisms. Indications for sulfadiazine (excluding combinations of the drug and trimethoprim) are: 1. Treatment and prevention of epidemic cerebrospinal meningitis caused by sensitive meningococci. 2. When combined with trimethoprim, it can treat otitis media and skin and soft tissue infections caused by sensitive Haemophilus influenzae, Streptococcus pneumoniae and other streptococcus. 3. Nucarbiosis stellaris. 4. Adjuvant to the treatment of chloroquine-resistant falciparum malaria. 5. A secondary drug for the treatment of cervicitis and urethritis caused by Chlamydia trachomatis. 6. A secondary agent for the treatment of neonatal somatic conjunctivitis caused by chlamydia trachomatis.



[Specification model] 0.5g*100s



Usage and Dosage 1. For the treatment of general infection in adults, the usual dose is taken orally, 1g once, twice a day, and the first dose is doubled. For infants and children over 2 months old, oral dosage is 25 ~ 30mg/kg once according to body weight, twice a day, and the first dose is doubled (the total dose is not more than 2g). 2. Preventing epidemic cerebrospinal meningitis in adults is usually taken orally, 1g once, twice a day, for a course of 2 days. Over 2 months of infants and children, 0.5g daily, 2 ~ 3 days of treatment.



[Adverse Reactions] 1. Allergic reactions are relatively common, which can be manifested as drug eruption. In severe cases, erythema multiforme exudative, dermatitis exfoliative and epidermolytic atrophic dermatitis bullous may occur. Also have performance for photosensitive reaction, drug heat, joint and muscle pain, fever and other serum disease like reaction. 2. Neutropenia or deficiency, thrombocytopenia and aplastic anemia. Patients may present with sore throat, fever, pallor, and bleeding tendencies. Hemolytic anemia and hemoglobinuria. Deficiency of glucose-6-phosphate dehydrogenase is more common in neonates and children than in adults after sulfonamides are used. Hyperbilirubinemia and neonatal nuclear jaundice. Because sulfonamide and bilirubin compete for the protein binding site. Can cause free bilirubin heighten. Neonatal liver function is not perfect, it is easy to produce high bilirubinemia and neonatal jaundice, occasionally can produce nuclear jaundice. 5. Liver damage. Jaundice, liver dysfunction and acute liver necrosis may occur in severe cases. 6. Kidney damage. Crystalline, hematuria, and tubular uria may occur. Severe adverse reactions such as interstitial nephritis or renal tubular necrosis occurred occasionally. 7. Nausea, vomiting, gastric hypopnea, diarrhea, headache, fatigue, etc., the general symptoms are mild, and do not affect the continuation of medication. Occasionally, patients develop C. difficile enteritis, at which point medication should be discontinued. 8. Goitre enlargement and hypofunction occur occasionally. 9. Toxic reactions of the central nervous system may occasionally occur and manifest as delirium, disorientation, hallucinations, euphoria, or depression. Once present, the drug should be discontinued immediately. Severe adverse reactions caused by this product are rare, but can be fatal, such as exudative erythema multiforme, exfoliative dermatitis, bullae epidermolytic atrophic dermatitis, fulminant hepatic necrosis, granulocytosis, aplastic anemia and other blood system abnormalities. Treatment should be monitored closely and discontinued when there are early signs of a rash or other reaction.



1. It is contraindicated for those allergic to sulfonamides; 2. Pregnant women and lactating women are prohibited; 3. It is prohibited for infants under 2 months old; 4. It is contraindicated for patients with liver and kidney dysfunction.



1. The following conditions should be used with caution: deficiency of glucose-6-phosphate dehydrogenase, hematoporphyria, water loss, shock, and elderly patients; 2. Cross allergic reactions. Patients who are allergic to one sulfonamides may be allergic to other sulfonamides; 3. Patients who are allergic to furosemide, sulfones, thiazide diuretics, sulfonylureas, and carbonic anhydrase inhibitors may also be allergic to sulfonamides; 4. Drink plenty of water each time you take this product. During the administration, adequate water intake should be maintained so that the daily urine volume of adults should be at least 1200ml or more. If the application of this product course of treatment is long, when the dose is large, in addition to drinking more water should be taken with sodium bicarbonate; 5. Attention should be paid to examination during treatment: (1) Complete blood examination is particularly important for patients receiving a longer course of treatment. (2) Periodic urine examination during treatment (routine urine examination every 2 ~ 3 days) to detect crystallization urine that may occur during a long course of treatment or high dose treatment. (3) Liver and kidney function examination. 6. The concentration of free sulfonamides should be measured in the blood of severely infected patients. The concentration of free sulfonamides should be 50 ~ 150& Mu for most infectious diseases. G /ml (severely infected 120 ~ 150& Mu; G /ml) can be effective. Total sulfonamide blood concentration should not exceed 200& Mu; G /ml, if more than this concentration, the incidence of adverse reactions increased; 7. Due to the low solubility of this product in urine, the chance of crystallizing urine is increased. Therefore, it is generally not recommended for the treatment of urinary tract infections; 8. Do not arbitrarily increase the dose, increase the number of medication or prolong the course of treatment to prevent accumulation of poisoning. 9. Because this product can inhibit the growth of Escherichia coli, hinder the synthesis of B vitamins in the intestine, so the use of this product for more than a week, should be given B vitamins to prevent its deficiency. Please read the instructions carefully and follow the doctor's advice.



[Children's medication] Because sulfonamide drugs can compete with bilirubin in the binding site of plasma protein, and the acetyltransferase system of newborns is not fully developed, and the free blood concentration of sulfonamide increases, thus increasing the risk of nuclear jaundice. Therefore, such drugs are contraindicated in newborns and infants under 2 months of age.



[Elderly patients with medication] The application of this product in elderly patients has increased the chance of serious adverse reactions. Severe skin rashes, myelosuppression and thrombocytopenia are common serious adverse reactions in the elderly. Therefore, the application should be avoided in elderly patients, and the decision should be made after weighing the advantages and disadvantages when there are definite indications.



1. This product can pass through the blood placenta barrier to the fetus, and has teratogenicity in animal experiments. Human studies lack sufficient data and should be avoided by pregnant women; 2. This product can be secreted from the milk, the concentration in the milk can reach about 50% ~ 100% of the maternal blood drug concentration, the drug may have an effect on the Suckling. The use of this product in neonates with glucose -6- phosphate dehydrogenase deficiency may lead to hemolytic anemia. For the above reasons, lactating women should not use this product.



[Drug interaction] 1. The combination of uretic alkalinizing drugs can increase the solubility of this product in alkaline urine and increase excretion. 2. Can not be used with p-aminobenzoic acid, p-aminobenzoic acid can be taken in place of this product by bacteria, the two antagonize each other. It is also not suitable to be combined with local anesthetics containing p-aminobenzoyl, such as procaine, benzocaine, tetracaine, etc. 3. When used together with oral anticoagulants, oral hypoglycemic agents, methotrexate, phenytoin sodium and thiopental sodium, the dosage of the above drugs should be adjusted, because this product can replace the protein binding site of these drugs, or inhibit their metabolism, leading to prolonged drug action time or toxicity. 4. Combined use with myelosuppressants may enhance the potential for adverse reactions to such drugs. When a combination of two drugs is indicated, close observation should be made for possible adverse reactions. 5. Combined with birth control pills (including estrogen) for a long time can reduce the reliability of contraception and increase the chance of bleeding during menstruation. 6. The potential toxicity may be enhanced when used in combination with thrombolytic drugs. 7. Combined use with hepatotoxic drugs may increase the incidence of hepatotoxicity. Such patients should be closely monitored, especially those who have been on medication for a long time and have a history of liver disease. 8. When combined with photosensitive drugs, photosensitive action may be added. 9. Patients receiving this product have an increased need for vitamin K. 10. It is not suitable to use with Ulotropine, because Ulotropine can be decomposed in acidic urine to produce formaldehyde, which can form insoluble precipitate with this product, increasing the risk of crystallizing urine. 11. This product can replace the plasma protein binding part of butazone. When used together, the effect of butazone can be enhanced. 12. Because this product may interfere with the bactericidal action of penicillin drugs, it is best to avoid using it with such drugs. 13. When used in combination with the product, it can reduce the secretion of the product from the renal tubules, resulting in a prolonged or toxic increase in the blood concentration. Therefore, it may be necessary to adjust the dosage of the product during or after the application of the product.



[Drug overdose] Sulfanilamide blood concentration should not exceed 200& mu; G /ml, if the concentration is more than this, the incidence of adverse reactions is increased and toxicity is enhanced.



[Pharmacological toxicology] This product belongs to sulfonamides, which has antibacterial effect on non-enzymolytic Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella and other enterobacteriaceae bacteria, Neisseria gonorrhoeae, Neisseria meningitidis and Haemophilus influenzae. In addition, it also had anti-microbial activity against Chlamydia trachomatis, Nucardia stellaris, Plasmodium falciparum and Toxoplasma gondii in vitro. The antibacterial activity of this product is similar to that of sulfamethoxazole. But in recent years, the resistance of bacteria to this product increased, especially Streptococcus, Neisseria and Enterobacteriaceae bacteria. Sulfonamides are broad-spectrum bacteriostatic agents. This article structurally similar to aminobenzoic acid (PABA), can be competitive effect on bacteria and PABA dihydrofolate synthetase, preventing PABA folic acid as raw materials needed for the bacteria, reduce the metabolic activity of four hydrogen folic acid, while the latter is the synthesis of purines and thymine bacteria nucleoside and deoxyribonucleic acid (DNA) necessary material, Therefore inhibit the growth and reproduction of bacteria.



[Pharmacokinetics] This product is rapidly absorbed by oral administration and can absorb more than 70% of the dose. After a single oral administration of 2g, the peak concentration of free blood drug (Cmax) is about 30-60mg /L. The distribution of this product in the body is similar to that of sulfamethoxazole, and it can pass through the blood-cerebrospinal fluid barrier. When the meninges are not inflamed, the drug concentration in the cerebrospinal fluid is about 50% of the blood drug concentration, and when the meninges are inflamed, the drug concentration in the cerebrospinal fluid is about 50% ~ 80% of the blood drug concentration. The blood elimination half-life (T1/2β) of the drug was about 8 ~ 13 hours in normal renal function patients, and the elimination half-life (T1/2β) of the drug was prolonged in renal failure patients. 60% ~ 85% of the dose of the drug was excreted from the urine in its original form within 48 ~ 72 hours after administration. Drugs in the urine solubility is low, prone to crystallizing urine. Peritoneal dialysis could not excrete this product, and hemodialysis only cleared it moderately. The protein binding rate of this product is 38% ~ 48%.



To shield from light and keep sealed.



[Packed] 100 tablets/bottle



[Effective period] 36 months



[Executive standard] Chinese Pharmacopoeia 2010 edition of the second



[Approval Number] National medicine approval H44020937





FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

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Our Service
a)  Free amples can be provided.
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c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
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6. Competitive price: discounts will be obtained when making large orders.

Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.


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