Tazobactam sodium
Name: Tazobactam sodium
CAS: 89785-84-2
Molecular Formula: C10H11N4NaO5S
Molecular Weight: 322.273
Tazobactam sodium - Names and Identifiers
| Name |
Tazobactam sodium |
| Synonyms |
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt, (2S,3S)- (1:1)
sodium (2S,3S)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
| CAS |
89785-84-2 |
| InChI |
InChI=1/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m0./s1 |
Tazobactam sodium - Physico-chemical Properties
| Molecular Formula |
C10H11N4NaO5S |
| Molar Mass |
322.273 g/mol |
| Use |
Is an irreversible competitive β-lactamase inhibitor |
Tazobactam sodium - Risk and Safety
| Safety Description |
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes. |
Tazobactam sodium - Tazobactam sodiumsalt: Cio HU N4NaoS.CAS accession number [89785-84-2]. Amorphous solid, melting point> 170 °c (decomposition). Soluble in water, slightly soluble in methanol, ethanol, insoluble in acetone, ethyl acetate, ether.
Last Update:2022-01-01 08:52:35
Tazobactam sodium - Preparation Method
with sulbactam as raw material, the carboxyl group was protected by alcoholization, and then reacted with sodium azide to introduce an azide group on the methyl group. Reaction with vinyl acetate to form a triazole compound, and finally the hydrogen is freed from the protecting group to give tazobactam. Alternatively, 6-APA (6-aminopenicillanic acid) is used as a raw material, which is subjected to diazotization, bromination, peracetic acid oxidation, and then alcoholization, and then debromination is carried out under the action of zinc. It is then reacted with the trimethylsilyltriazole compound, the triazole compound is introduced, the potassium permanganate is oxidized, and finally the sodium tazobactam is hydrolyzed.
Last Update:2022-01-01 08:52:36
Tazobactam sodium - Use
Japan Dapeng (Taiho) company research and development. p-lactamase inhibitors. For clinically important beta-lactamases such as penicillinase produced by S. Aureus, Proteus, Bacteroides, the chromosome-mediated p-lactamases produced by Klebsiella pneumoniae have a strong inhibitory effect. The width of the enzyme spectrum and the intensity of inhibition of enzyme activity were better than those of clavulanic acid and sulbactam. Its low toxicity, good stability, strong inhibition of enzyme activity. For the treatment of a variety of bacteria including aerobic and anaerobic bacteria caused by infection, including lower respiratory tract infections, skin and abdominal infections.
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