Pharmaceutical Bioreactor, Industrial Bioreactor 100 Liters

• Type: Preparation Machinery
• Finished Dosage Form: Liquid
• Precision: High Precision
• Certification: GMP, ISO
• Voltage: Customized
• Computerized: Computerized
• Model NO.: Fermentor Bioreactor-001
• Customized: Customized
• Condition: New
• Warranty: 1 Year
• Model No.: 100L
• Sample: 1set
• Name: Bioreactor
• Sample Cost: Tbd
• Transport Package: Exportable Wooden Box
• Trademark: FUL
• Origin: China
• HS Code: 84798999
• Production Capacity: 300

Product Description

Product Description

 

Feature description:
The cell reactor is used to complete the cell culture process from seed expansion to production culture, including the transfer and mixing of various materials, the precise control and display of temperature, pressure, pH, DO (dissolved oxygen), foam, liquid level and volume as well as the amount of alkali replenishment, replenishment volume, replenishment rate, the aseptic filtration, measurement and display of incoming air, oxygen, carbon dioxide and nitrogen (if any), the good control of condensation, heating and aseptic filtration of exhaust , the necessary online cleaning and sterilization operations during the production process, etc.
The ability to meet the temperature, pressure, pH, DO, foam and other requirements of existing production processes at the maximum working volume. The control of liquid level, cell density increased 5-15 times in 48h-72h after inoculation of CHO cells, with densities of 2.0×105Cells/mL-4.0×107Cells/mL. All parameters of the tank can be controlled.
The cell culture process from seed expansion to production culture, including the transfer and mixing of various materials, the precise control and display of temperature, pressure, pH, DO (dissolved oxygen), foam, liquid level and volume, as well as the amount of alkali replenishment, the amount of replenishment, the rate of replenishment, the aseptic filtration, measurement and display of added air, oxygen, carbon dioxide, nitrogen (if any); good control of the condensation, heating and aseptic filtration of emissions; the necessary online cleaning and sterilization operations in the production process.

 

Product Parameters

Speed control	Intelligent automatic PID control, pulse width modulation rare earth DC motor +  gearbox, stirring speed: 50-1000rpm, variable speed, accuracy ± 5 ‰
DO control	PID intelligent automatic control, imported Swiss electrodes and cables, measuring range: 0-150%, control accuracy: ± 3%. Resolution 0.1%, according to the fermentation process controlled by fermentation time sequence(DO automatic variable control, multi-segment), can associated control with speed, air flow, pressure, feeding and other parameters
PH control	Intelligent PID automatic control, imported Swiss electrodes and cables, two peristaltic pumps. Display range: 0.00 to 14.00 ± 0.01, control range: 2.00 to 12.00 ± 0.02. Online detection, automatic alarm, automatically add acid/alkali solution by peristaltic pump  pH value curve analysis, acid/alkali volume curve analysis, quantitative analysis batch report, The cumulative amount of acid/alkali added display records, Control the fermentation process by fermentation time sequence (pH automatic variable controller, multi-segment)
Temperature control	Intelligent PID automatic control,  thermostatic bath + PT100 temperature sensor + electric heating + solenoid valve range; cooling water temperature +3 -60 ºC, accuracy of ± 0.2 ºC, 0.1 ºC resolution
Feeding control	Air ratio control switch can be set to 1-100%, automatic flow and measured. Supplement feeding amount curve analysis, the amount accumulated, display records, save of batch reports analyze. Control the fermentation process segment by fermentation time sequence(automatic feeding variables, multi-segment) . Dedicated pins and needles feeding sets, to ensure safe operation of feeding.
Defoaming control	Intelligent PID automatic control, electrode detection, adding defoamer by peristaltic pump, sensitivity 100-100000Ω, can supplement quantitative and timing.
Ventilation	Manual adjustment, the flow meter measure, ventilation 1: 1-2VVM
Pressure	Manual adjustment, pressure gauge measure ,the range 0-0.2MPa
Sterilization	Manual adjustment, the program assisted sterilization, sterilization reign / off-site.
Control system	Based on the German scene controller S7-200 Siemens programmable logic controller series as the core.  Imported 5.7 "true color touch screen. Independent control software, matte stainless steel control cabinet. Data processing can be performed and the curve displayed Data A / D or D / A conversion, data capture to display, each control loop tuning PID operation and setpoint control, timing control and host communications.
Exhaust	Stainless steel exhaust condenser exhaust
Function	PC remote control  Automatic sterilization  Exhaust O2, CO2 detection  Oxidation-reduction detection  Automatic ventilation  Automatic tank pressure Tank Weighing  Feeding Weighing Online precisely calculated important parameters  OUR, CER, RQ, KLα, etc.,which indirectly reflect  the changes in cell metabolism stream.

 Features

1. With low shear force and good mixing effect, it can meet the requirement of free suspension cell culture. 
2. Equipped with aself-cleaning liquid change tube, which can meet the requirement of up to 5 times the culture volume flow per day under continuous culture conditions without clogging. 
3. Unique bubble-free ventilation device. Completely solve the damage of air bubbles to cells under various culture conditions, and at the same time reach the oxygen transfer rate of 10ml/L/Hr to meet the requirements of high density culture. 
4. Innovative sterilization sampling device. In any case, you can sample, observe, and test.
5. All connections are hygienic, simple and convenient.
6. Combination of surface ventilation and deep ventilation.
7. The open design of pipes and pipe racks is convenient for use and maintenance.
8. The control system uses industrial programmable logic control elements from Siemens. The system is open and can replacedamaged modules online. 
9. The parameter control adopts deviation tolerance control, and the control parameters are stable without fluctuation. 
10. Two stable reference points are adopted for stability, and the temperature is stable and reliable.
11. The stirring speed can be set as a function of time to meet the requirements of stirring speed in different cultivation periods. 
12. The software system has the function of automatically diagnosing each subsystem, which is convenient for overhaul and maintenance. 
13. Control is based on Windows Ce operating system, simple and easy to learn. 
14. Comply with GMP/cGMP requirements.

Certifications

 

Our Advantages

 

FAQ

1. Are you a factory or a trading company?

Answer: We are a factory.


2. What is MQQ?

Answer: 1 unit.
 

3. Do you provide overseas services?

Answer: Yes, we can send engineers overseas.


4. Can we visit your factory?

Answer: Yes, you are very welcome.

 
5. What is your delivery time?

Answer: 2 weeks to 3 months. It depends on the size and quantity.